Scientific References & Ingredient Clinical Studies

Peer-Reviewed Cosmetic Science

Elevion formulations incorporate cosmetic ingredients with documented activity in peer-reviewed scientific literature. The studies referenced below evaluate individual ingredients and biological mechanisms commonly used in dermatologic and cosmetic science. These references do not imply that Elevion products diagnose, treat, cure, or prevent any disease.

Barrier Support & Hydration

Multi-Level Hyaluronic Acid (Sodium Hyaluronate)

Hyaluronic acid is a naturally occurring glycosaminoglycan studied extensively for its ability to support skin hydration, improve skin surface smoothness, and reduce transepidermal water loss (TEWL). Molecular weight influences depth of hydration and surface conditioning.

Published findings include:

• 
  Skin hydration increase: up to +96% following topical application
  
• 
  TEWL reduction: approximately 20–30%
  
• 
  Improved skin smoothness and elasticity: observed within 4–8 weeks
  

References:

Pavicic et al., Journal of Drugs in Dermatology, 2011

Papakonstantinou et al., Dermato-Endocrinology, 2012

Glycerin

Glycerin is a gold-standard humectant widely used in dermatologic formulations to support stratum corneum hydration and barrier recovery.

Published findings include:

• 
  Stratum corneum hydration improvement: +30–50%
  
• 
  Barrier recovery acceleration: following barrier disruption
  
• 
  Improved corneocyte maturation and cohesion
  

References:

Fluhr et al., British Journal of Dermatology, 2008

Panthenol (Pro-Vitamin B5)

Panthenol has been shown to support skin comfort, hydration, and barrier function, particularly in formulations intended for sensitive or compromised skin.

Published findings include:

• 
  Hydration increase: approximately +20–30%
  
• 
  Improved skin softness and elasticity
  
• 
  Reduction in visible irritation and roughness
  

References:

Ebner et al., American Journal of Clinical Dermatology, 2002

Gehring & Gloor, Skin Pharmacology and Physiology, 2000

Skin Barrier Lipids

Ceramides, Cholesterol & Fatty Acids

Barrier lipid systems designed to mimic the skin’s natural lamellar structure have been shown to support barrier integrity and moisture retention.

Published findings include:

• 
  TEWL reduction: 20–40%
  
• 
  Barrier integrity improvement: measurable within 2–4 weeks
  
• 
  Enhanced lipid organization and resilience
  

References:

Elias & Feingold, Clinical Dermatology, 2014

Chamlin et al., Journal of the American Academy of Dermatology, 2002

Peptides & Skin Conditioning Agents

**Matrixyl® 3000

(Palmitoyl Oligopeptide & Palmitoyl Tetrapeptide-7)**

Cosmetic peptides have been evaluated for their role in supporting extracellular matrix signaling and improving the appearance of skin smoothness and wrinkle depth.

Published findings include:

• 
  Reduction in wrinkle depth: up to 15–30%
  
• 
  Improved skin smoothness and firmness
  
• 
  Support of collagen-associated signaling pathways (cosmetic mechanism)
  

References:

Robinson et al., International Journal of Cosmetic Science, 2005

Sederma ingredient research summaries (cosmetic ingredient literature)

Tripeptide-29

Tripeptide-29 has been evaluated in in-vitro studies for its association with collagen expression and is used in advanced cosmetic formulations focused on skin conditioning.

Published findings include (in-vitro):

• 
  Collagen expression increase: reported up to 300–400% in fibroblast cultures
  
• 
  Support of extracellular matrix organization
  

Reference:

Lee et al., Journal of Cosmetic Dermatology, 2015 (in vitro)

Centella Asiatica (CICA)

Centella Asiatica has been studied for its role in supporting skin comfort, barrier resilience, and visible redness reduction.

Published findings include:

• 
  Reduction in visible redness: 20–30%
  
• 
  Improved barrier recovery
  
• 
  Support of antioxidant and soothing pathways
  

References:

Byun et al., International Journal of Molecular Sciences, 2018

Bylka et al., Phytotherapy Research, 2013

Skin Microbiome Support

Alpha-Glucan Oligosaccharide (Prebiotic Technology)

Prebiotic ingredients have been studied for their ability to support a balanced skin microbiome and improve overall skin comfort.

Published findings include:

• 
  Increase in beneficial skin flora: +20–40%
  
• 
  Reduction in skin discomfort and imbalance
  
• 
  Improved skin barrier tolerance
  

References:

Guéniche et al., British Journal of Dermatology, 2010

Knackstedt et al., Journal of Drugs in Dermatology, 2020

Important Disclosure
The studies referenced above evaluate individual cosmetic ingredients and biological mechanisms under controlled conditions.
Product performance may vary based on formulation, skin type, and usage.
Elevion products are cosmetic formulations intended to support the appearance, comfort, and conditioning of the skin.
They are not intended to diagnose, treat, cure, or prevent any disease.